3-[(1H-Benzo[d][1,2,3]triazol-1-yl)oxy]propyl 9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate
نویسندگان
چکیده
We herein report on the synthesis of a pentacyclic triterpene functionalized through derivation betulinic acid with hydroxybenzotriazole. The compound was fully characterized by proton (1H-NMR), carbon-13 (13C-NMR), heteronuclear single quantum coherence (HSQC) and distortionless enhancement polarization transfer (DEPT-135 DEPT-90) nuclear magnetic resonance. Ultraviolet (UV), Fourier-transform infrared (FTIR) spectroscopies as well high-resolution mass spectrometry (HRMS) were also adopted. Computational studies conducted to foresee interactions between 3 phosphodiesterase 9, relevant target in field neurodegenerative diseases. Additionally, preliminary calculation physico-chemical descriptors performed evaluate drug-likeness 3.
منابع مشابه
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متن کامل(E)-3-(9-Anthryl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one
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ژورنال
عنوان ژورنال: Molbank
سال: 2022
ISSN: ['1422-8599']
DOI: https://doi.org/10.3390/m1419